2013年7月5日星期五

What causes Interstitial Nephritis

Interstitial nephritis can be divided into acute interstitial nephritis and chronic interstitial nephritis. Here, we will talk about the causes of acute interstitial nephritis and chronic interstitial nephritis.
Acute Interstitial Nephritis Causes
1. Drugs: antibiotics and nonsteroidal anti-inflammatory drugs and analgesics, anti-seizure drugs, diuretics, proton pump inhibitors, etc.
2. Infection: bacteria, viruses, parasites and mycoplasma, chlamydia, etc.
3. Autoimmune diseases: systemic lupus erythematosus (sle), sarcoidosis, mixed cold globulin hematic disease, ANCA associated vasculitis, etc.
4. Malignant tumor: lymphoma, leukemia, multiple myeloma, light chain deposition disease, etc.(Learn About: Factors that Affect Prognosis of Glomerulonephritis)
5. Metabolic disease: diabetes, high uric acid hematic disease;
6. Idiopathic acute interstitial nephritis.
Chronic Interstitial Nephritis Causes
1. Genetic disease: such as familial interstitial nephritis, polycystic kidney disease, medullary cystic lesion and hereditary nephritis;
2. Drug-induced kidney disease: kidney damage caused by some drugs, such as non-steroidal anti-inflammatory drugs, aristolochic acid drugs, ciclosporin and cisplatin, etc.
3. Urinary tract disease: obstructive nephropathy, reflux nephropathy;
4. Infectious diseases: chronic pyelonephritis caused by a variety of pathogens;
5. Heavy metal poisoning: such as lead, cadmium, lithium intoxication;
6. Physical damage: such as radioactive kidney disease;
7. Systemic disease: autoimmune disease (systemic lupus erythematosus and sjogren′s syndrome, cold globulin hematic disease, chronic graft rejection reaction); metabolic disease (uric acid nephropathy, hypercalcemia kidney disease, low potassium renal disease); blood disease (multiple myeloma, light chain deposition disease).

If you have any other questions about interstitial nephritis, you can send an email to kidneyask@hotmail.com

Expert Online