Positively control immune inflammatory response; restrain glomerular mesentery proliferative lesion; prevent and delay the forming of chronic renal fibrosis lesion.
Pain killers may be needed for the abdominal and joint pains. It is uncertain
as to whether HSP needs treatment beyond controlling the symptoms. Most patients
do not receive therapy because of the high spontaneous recovery rate. Steroids
are generally avoided.However, if they are given early in the disease episode,
the duration of symptoms may be shortened, and abdominal pain can improve
significantly. Moreover, the chance of severe kidney problems may be
reduced.However, some evidence suggests that steroids do not decrease the
likelihood of developing long-term kidney disease.
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Evidence of worsening kidney damage would normally prompt a kidney biopsy.
Treatment may be indicated on the basis of the appearance of the biopsy sample;
various treatments may be used, ranging from oral steroids to a combination of
intravenous methylprednisolone (steroid), cyclophosphamide and dipyridamole
followed by prednisone. Other regimens include steroids/azathioprine, and
steroids/cyclophosphamide (with or without heparin and warfarin). Intravenous
immunoglobulin (IVIG) is occasionally usually.
PN, whose clinical presentations are progressive nephritis and a large number
of crescents (>50%) formation in kidney biopsy, has a high risk of developing
terminal renal failure. For these severe cases, they should be take positive
measures, such as plasma exchange. It’s indicate in clinical practice that using
hormone and cytotoxic drugs, using together with plasma exchange,or using plasma
exchange alone, can reduce renal damage and delay the development of renal
Overall prognosis is good in most patients, and the prognosis is better in
children than adults. The prognosis is almost perfect for patients with single
hematuria. And the prognosis for patients with different levels of proteinuria
[(<1g/24h,>1g/24h) and Nephrotic Syndrome] is related to renal
ingravescence. The prognosis for patients with Acute Nephritis Syndrome is bad.
Most of them will develop End-stage Renal Disease (ESRD)
1.Some cases do not receive treatment because of the high spontaneous
recovery rate, especially for mild cases.
2.Before occurring to rash, pay attention whether patients touched the
suspected food and foreign matter causing allergy. Avoid to touching again.
3.Patients with PN should be given the different treatments according to
ages, clinical presentations and levels of kidney damage.
4 For the patients with severe clinical symptoms or diffuse pathological
lesions, and crescent formation, they should use hormone together with
immunosuppressive drugs to control the disease development as soon as
5. For the patients having taken hormone, they should decrease the dosage and
times under the doctor’s guidance. Never stop the drugs casually.